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April 16, 1927


JAMA. 1927;88(16):1237. doi:10.1001/jama.1927.02680420027014

In a recent issue of The Journal, 1 the increasing evidences that so-called normal urine does not contain glucose, the sugar of the circulating blood, were commented on. It may be argued that the discussion of this much debated topic ought now to be brought promptly to a conclusion. The problem of the urinary occurrence of any proximate principle, whether it be protein, fat or carbohydrate, is assuredly of such significance that it deserves respectful consideration at all times. The fact that products having at least the semblance of carbohydrate nature can be detected in practically every urine affords an ever recurring occasion for attempting to elucidate their presence. Furthermore, the explanation of their occurrence should throw more light on the question of the actual extent to which the kidneys are normally impermeable to blood sugar.

Through research done in the medical clinic of the Johns Hopkins University, Eagle2