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January 10, 1931


JAMA. 1931;96(2):128-129. doi:10.1001/jama.1931.02720280046021

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The Pernicious Types of Malaria  Prof. Ettore Marchiafava, senator, delivered recently in Rome, at the Scuola superiore di malariologia, a lecture on the pernicious aspects of malaria. The plurality of the parasites in the various types of malaria is now universally admitted. The various pernicious types, however, constitute a pathologic entity of unique etiology, represented by Plasmodium falciparum. The red corpuscles invaded by this parasite shrivel; it is possibly the modification in their physicochemical quality that is the cause of the important fact that the multiplication of the plasmodium occurs in the smallest vessels of the internal organs. That results sometimes in the blocking of the brain, which leads to progressive and retrogressive secondary changes. The gametes of Plasmodium falciparum assume the crescent form, develop in the bone marrow, and a few days after the onset of the disease are found in the peripheral blood. Prompt and well executed treatment

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