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January 10, 1931


JAMA. 1931;96(2):129-130. doi:10.1001/jama.1931.02720280047022

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Carbohydrate Metabolism and Insufficiency of Hypophysis  Drs. Houssay and Biassotti presented before the International Congress of Biology, recently held at Montevideo, Uruguay, the results of experiments which seemed to prove that the hypophysis is the most important regulating factor of carbohydrate metabolism. Basal metabolism in hypophysioprival dogs is on an average 15 per cent lower than in controls. The administration of meat to eight hypophysioprival dogs and to six controls caused the same dynamic action. Hypophysioprival dogs eliminate 30 per cent less nitrogen per kilogram of body weight than the controls do. They have a normal glycemia. Occasionally they present spontaneous crises of hypoglycemia. If, during the crises, the glycemia drops to 0.7 per thousand, the animals develop convulsions and go into coma. As a rule these crises appear when the animals are fasting, especially if they have received phlorhizin, and may be observed both in dogs deprived only of

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