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December 2, 1933

Le rôle biologique de la catalase dans le métabolisme d'énergie.

JAMA. 1933;101(23):1825. doi:10.1001/jama.1933.02740480057035

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In this monograph on catalase action the author reviews the earlier theories as to the action and function of catalase, also the more modern views on the liberation of energy in metabolism. Each theory is discussed and its defects and values are presented. The peroxidase and pH factors are treated separately in some detail, after which the author presents his own views and his own theory. He points out that oxidative metabolism can be considered as a two phase process in which the anaerobic and aerobic phases proceed independently but rhythmically. The rhythm is controlled in the main by the pH of the fluids at the surfaces of cells and by the effects of pH changes in the activation and inactivation of the enzymes involved in these processes. The local pH changes the author considers to be automatically controlled by insulin through its control of fatty

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