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April 23, 1927


JAMA. 1927;88(17):1322. doi:10.1001/jama.1927.02680430024011

The association by the biochemist of cholesterol with bile is one not only of name but also of fact. While the amount of this unique alcohol is small in bile, attention has been focused on it because of the fact that gallstones are usually composed more or less of cholesterol. Although definite progress has been made in the chemistry of cholesterol, 1 the metabolism of this substance has not yet been clearly defined. While the biliary cholesterol is generally considered to be an excretion, the observed relationships between blood and bile sterol have not always supported this conception. Moreover, investigations of the subsequent absorption of this cholesterol through the intestinal wall have not yielded consistently positive results. Studies of its synthesis carried out by analyzing intake in the food and output in the feces have led, in general, to the conclusion that some organ or group of organs in the