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April 23, 1927


JAMA. 1927;88(17):1322-1323. doi:10.1001/jama.1927.02680430024012

The cerebrospinal fluid has been familiar to physiologists for more than a century, since it was first described in a clear-cut manner by the distinguished French scientist François Magendie, in 1825. Keen interest in the fluid and its functions was not exhibited, however, until a comparatively recent date. The current attention to the subject is in large measure due to the introduction of lumbar puncture into clinical medicine. The operation is performed ordinarily either for the purpose of relieving intracranial pressure, as in hydrocephalus, or for collecting cerebrospinal fluid for diagnostic use. According to a recent writer, 1 the established facts regarding the fluid include its origin in the choroid plexus, the perivascular spaces contributing a small additional amount. Absorption of the fluid takes place chiefly through the arachnoid villi into the venous sinuses of the skull, a small amount of fluid being absorbed along the cranial and spinal nerve