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April 23, 1927


JAMA. 1927;88(17):1323-1324. doi:10.1001/jama.1927.02680430025013

The actual daily requirement for iron in the case of the human adult is at present assumed to amount to only a few milligrams of the element. From the quantitative standpoint it would appear, therefore, as though the problem of iron in nutrition should cause little concern. Perhaps this accounts for the seeming neglect of the subject until quite recently. A large part of the iron contained in the body is confined to the blood, where it courses as an integral part of the hemoglobin of the red blood corpuscles. The clinic of human disorders affords numerous illustrations of shortage of the oxygen-carrying erythrocytes; and this condition can be imitated to some extent in experimental ways for purposes of the study of anemia. For many years the latter has been interpreted as a lack of iron, a thesis substantiated by the fact that it is actually possible to induce anemia