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April 23, 1927


JAMA. 1927;88(17):1337. doi:10.1001/jama.1927.02680430039021

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Postvaccinal Encephalitis  Reference has been made to certain untoward incidents that occasionally occur following smallpox vaccination. The discussion of this question is reopened because of an account of the researches of Bastiaanse, Bijl and Terburgh that recently appeared in the Nederlandsch Tijdschrift voor Geneeskunde. The study is based on thirty-five cases of postvaccinal encephalitis observed between Jan. 1 and July 1, 1925. These cases developed from ten to thirteen days after vaccination, and fifteen, or 43 per cent, proved fatal. The cases occurred, in the main, in small places, often adjacent to one another, and, in some instances, more than one case in one commune. Most of the cases were notified in March, in which month the epidemic was more widespread than in the other months of the year. The vaccine that was used to vaccinate the children who developed encephalomyelitis came from three different establishments and had been derived

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