The final evaluation of any system for the treatment of patients with early syphilis must, in the nature of the disease, depend on long term post-treatment observation of a large group of patients. This principle has long been recognized, especially by those who of necessity have attempted the evaluation of modern treatment methods on the basis of a few patients followed for long periods, and larger series in which the period of observation was shorter.1 These previous authors have not purposely limited themselves; simply because of the time intervals involved, no large group of patients followed for long periods after modern treatment for early syphilis has heretofore been available. It is now possible partially to supply this deficiency.
From among the patients with early syphilis who had been admitted to the syphilis division it was possible to find 551 who had been completely reexamined five or more
PADGET P. LONG-TERM RESULTS IN THE TREATMENT OF EARLY SYPHILIS. JAMA. 1941;116(1):7–11. doi:10.1001/jama.1941.02820010009002
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