The concept of gonadotropic action of the anterior lobe of the pituitary gland arose from the experiments of Philip E. Smith in 1926, in which the treatment of immature rodents with implants of fresh anterior lobe produced follicular growth and the formation of corpora lutea. Similar effects were found at the same time in immature mice by Aschheim and Zondek, but Smith demonstrated that atrophy of the gonads follows hypophysectomy and that it may be prevented or the gonads repaired by treatment with fresh anterior pituitary implants.
Since this pioneer work, an amazing mass of literature concerning this subject has accumulated. It is beyond the scope of this chapter to consider all the work which has been reported. For such a comprehensive review the reader is referred to Van Dyke (1939).1 In the present article attention will be directed to those observations which appear to be most firmly established
ENGLE ET, LEVIN L. GONADOTROPINS OF THE ANTERIOR LOBE OF THE PITUITARY AND OF CHORIONIC TISSUE. JAMA. 1941;116(1):47–52. doi:10.1001/jama.1941.62820010003013
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