The history of the development of specific chemotherapy in medicine is well known. Startling discoveries of chemotherapeutic agents that have stood the test of time and experimentation have been rare indeed. Those now available to the medical profession are exceedingly few. The German school has continued this line of investigation with unremitting attention since the time of Ehrlich's discovery of the spirocheticidal action of arsphenamine, though elsewhere throughout the world there has been a general lack of interest except on the part of a few investigators.
In the United States, the therapeutic effect of various dyestuffs has been studied in recent years. We shall not attempt here to review the studies that have been made with this type of chemotherapy. The reports are ponderous, and if one were to draw a general conclusion from them it would be that the significant thing about them is the great variation in the
McKINLEY EB, HOLDEN M. DANGERS ATTENDING INTRASPINAL TREATMENT WITH MERCUROCHROME. JAMA. 1927;88(18):1391–1392. doi:10.1001/jama.1927.02680440025010
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