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Article
January 11, 1941

ADRENAL CORTEX EXTRACT IN THE TREATMENT OF BROMIDE ERUPTION AND BROMIDE INTOXICATION

Author Affiliations

OKLAHOMA CITY

JAMA. 1941;116(2):100-104. doi:10.1001/jama.1941.02820020010003
Abstract

Our purpose in this paper is to report the effect of adrenal cortex extract1 on the elimination of bromide and bromide effects, with special reference to bromide eruption and bromide intoxication. This report is based on our experience and the evidence accumulated from the treatment of five cases of bromide eruption and nine cases of bromide intoxication. Also we give the results of the study of ten cases of bromism which we had the opportunity of observing in epileptic patients at the Central State Hospital.

A short review of the pharmacology of bromides reveals that Bolgar2 in 1910 found that bromides were readily absorbed from mucous membranes and that in ligated intestinal segments the absorption of bromide was not delayed by the presence of chloride; but bromide delayed chloride absorption. There are a variety of opinions present in the literature dealing with the distribution of bromide between the

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