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December 16, 1933


Author Affiliations

From the Memorial Hospital.

JAMA. 1933;101(25):1933-1937. doi:10.1001/jama.1933.02740500013004

Observations pointing to the direct relation of specific tumors to certain ductless glands are increasing. To this number the relation of teratoma testis to the anterior lobe of the pituitary may now be added.

Since December, 1930, there have been observed at the Memorial Hospital 117 consecutive cases of teratoma testis in which the quantitative excretion of prolan A (the follicle-ripening hormone of the anterior pituitary body) has been determined by multiple observations. The technic of the quantitative modification of the Aschheim-Zondek test1 has been published elsewhere and need not be repeated at this time.

In all the cases in this series in which the tumor had been unaffected by treatment, prolan A was found in the urine in varying amounts. The factors which determine the urinary excretion of prolan A are as follows: (1) the embryonal character of the tumor, (2) the extent of the disease and (3) the

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