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December 16, 1933

HYPERINSULINISM, A DEFINITE DISEASE ENTITYETIOLOGY, PATHOLOGY, SYMPTOMS, DIAGNOSIS, PROGNOSIS AND TREATMENT OF SPONTANEOUS INSULOGENIC HYPOGLYCEMIA (HYPERINSULINISM)

JAMA. 1933;101(25):1958-1965. doi:10.1001/jama.1933.02740500038010
Abstract

Hyperinsulinism, also called the "hunger" disease because hunger, associated with weakness, nervousness and other manifestations of hypoglycemia, is the most constant symptom, has been known to exist for ten years.1 At least a hundred cases have been reported by American and European clinicians, surgeons and pathologists who have made thorough studies of all phases of hypoglycemia due to the hypersecretion of the islet cells of the pancreas. Sufficient data have accumulated in medical literature to warrant the discussion of hyperinsulinism as a definite disease entity. In this paper the effort will be made to outline the etiology, pathology, symptoms, diagnosis and treatment of hyperinsulinism as derived from published reports of many cases and from ten years' study of the disease.

DEFINITION  Hyperinsulinism, the antithesis of diabetes mellitus (hypoinsulinism), may be defined as a disease of the pancreas resulting from the spontaneous excessive secretion of insulin by the islands of

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