We feel that enough time has elapsed since the introduction of sulfamido compounds for some evidence to have accumulated as to the merits of these compounds in the treatment of septicemia. By septicemia is understood "a morbid condition which is due to the presence of pathogenic bacteria in the blood stream with the symptoms which are associated with this clinical syndrome."
In 1938 E. C. Rosenow Jr. with one of us1 reviewed the cases of septicemia which had been encountered at the Mayo Clinic over a period of three years, 1934 through 1936. During that time none of the sulfamido compounds were being used by us in the treatment of septicemia. The review of 1938 offered a control group of results which can be compared with results from the use of sulfamido preparations. Accordingly, from 1937 to 1939 inclusive, when sulfamido compounds were available, we collected a group of
HERRELL WE, BROWN AE. THE TREATMENT OF SEPTICEMIA: RESULTS BEFORE AND SINCE THE ADVENT OF SULFAMIDO COMPOUNDS. JAMA. 1941;116(3):179–183. doi:10.1001/jama.1941.02820030001001
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