Among the disturbances of the several functions of the anterior lobe of the pituitary, only two are susceptible to treatment with any assurance of success at present. These are dysfunctions in the supply of the growth-promoting and gonadotropic factors, which will be discussed in detail. Although the thyrotropic extracts of the anterior lobe of the pituitary have been shown to act in some persons, it has not yet been possible to secure sustained stimulation of the thyroid in hypothyroid patients.1 Neither is there adequate evidence to warrant routine irradiation of the pituitary in an attempt to reduce production of the thyrotropic substance in patients with persistent thyrotoxicosis. The factors involved in pituitary stimulation of the adrenal glands are still further removed from immediate application in human therapy. The dysfunctions known under such terms as "basophilism," "Cushing's syndrome" or "the adrenogenital syndrome" will be discussed in another article of this
SEVRINGHAUS EL. DYSFUNCTIONS OF THE ANTERIOR LOBE OF THE PITUITARY AND THEIR TREATMENT. JAMA. 1941;116(3):221–225. doi:10.1001/jama.1941.62820030002011
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