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Lab Reports
November 3, 2015

Implantable Device Attracts and Captures Early Metastatic Cells

Author Affiliations

Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2015;314(17):1788. doi:10.1001/jama.2015.13931

A newly developed scaffold implanted in the subcutaneous tissue of mice recruits and captures metastatic cancer cells and reduces tumor burden in solid organs (Azarin SM et al. Nat Commun. 2015;6:8094).

A team led by investigators at Northwestern University and the University of Michigan, in Ann Arbor, combined the microporous scaffolds composed of poly(lactide-co-glycolide), a biomaterial approved by the Food and Drug Administration, with an imaging system using inverse spectroscopic optical coherence tomography to allow for label-free detection of metastatic cancer cells at the scaffold implant site.