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Lab Reports
November 3, 2015

Plasma DNA Mapping May Have Broad Clinical Application

JAMA. 2015;314(17):1788. doi:10.1001/jama.2015.13933

Using genome-wide bisulfite sequencing of plasma DNA, investigators from China have developed a method for analyzing the major tissue contributors to circulating DNA (Sun K et al. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1508736112 [published online September 21, 2015]. The method, which assesses DNA methylation patterns, is also useful for identifying the tissue of origin of genomic aberrations found in plasma DNA.