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Comment & Response
November 10, 2015

Thrombophilia and the Risk of Recurrent Venous Thromboembolism—Reply

Author Affiliations
  • 1Département de Médecine Interne et Pneumologie, Centre Hospitalo-Universitaire de Brest, Brest, France
  • 2Service de Pneumologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France
  • 3Centre Hospitalo-Universitaire de Brest, Brest, France
JAMA. 2015;314(18):1976. doi:10.1001/jama.2015.12610

In Reply Dr Rhinehart and colleagues raise an important and controversial issue concerning the effect of thrombophilia on the risk of recurrent venous thromboembolism. They were concerned that the results of the PADIS-PE trial may be biased due to the inclusion of patients with identified and unidentified thrombophilia.

First, misclassification bias was avoided because thrombophilia testing was performed at the end of the study on stored frozen blood samples taken on the day of randomization using the same standardized laboratory techniques for all included patients by technicians blinded to the study treatment allocation.