The use of alkalis or the so-called antacids in the gastric hyperacidity syndrome is very old. The alkalis are used for the purpose of giving relief from the pain commonly experienced by patients with gastric or duodenal ulcer, and to promote healing of the ulcer. The most popular remedy of this type at the present time is sodium bicarbonate. Sippy 1 recommended in place of this his much used two powders, the first of which contains 0.7 Gm. (10 grains) each of heavy magnesium oxide and sodium bicarbonate, and the second, to be used alternately with the first, 0.7 Gm. (10 grains) of bismuth subcarbonate and from 1.2 to 1.8 Gm. (20 to 30 grains) of sodium bicarbonate. At another time Sippy recommended 0.7 Gm. (10 grains) of calcium carbonate in place of the bismuth subcarbonate in the second powder. Other similar powders containing one or more of these constituents
LOEVENHART AS, CRANDALL LA. CALCIUM CARBONATE IN TREATMENT OF GASTRIC HYPERACIDITY SYNDROME: AND IN GASTRIC AND DUODENAL ULCER. JAMA. 1927;88(20):1557–1559. doi:10.1001/jama.1927.02680460027007
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