In the course of routine examinations for Plasmodium vivax, used in the treatment of general paralysis, the early appearance of gametocytes was noted in a few instances. In six of our last cases of artificially inoculated malaria, we have obtained the data given in the accompanying table as to the time of the first appearance of gametocytes.
It is thus apparent that gametocytes of Plasmodium vivax are present in the infections produced by direct transfer of blood much earlier than in the generally accepted time of their appearance in naturally acquired malaria. Theoretically, gametocytes were present in the artificially induced cases of malaria in sufficient numbers to be infectious to mosquitoes, at least, in four of the cases cited, as early as the second and third days after the onset of the infections.
Craig1 has called attention to the fact that gametocytes occur in latent malaria in
St. John JH. THE EARLY APPEARANCE OF GAMETOCYTES IN ARTIFICIALLY INDUCED TERTIAN MALARIA. JAMA. 1927;88(20):1561. doi:10.1001/jama.1927.92680460030009a
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