The functions of the suprarenal glands have been the subject of such differences of opinion on the part of competent physiologists that a reviewer of the available evidence is likely to hesitate to promulgate any fixed conclusion. Nevertheless, the accumulating experimental facts are beginning to permit a marshaling of their bearings into the form of at least tentatively tenable points of view. The early demonstration of the pressor effects of the hormone epinephrine, liberated by the glands, naturally prompted the hypothesis that the secretion of these glands is a factor in the maintenance of arterial tone. Owing, however, to the lack of corroboratory indications and to the actual demonstration of contradictory facts, the "tonus" hypothesis has been abandoned. At best the actual amount of epinephrine constantly liberated could scarcely suffice to produce the desired effects. Furthermore, epinephrine is not present in sufficient concentration to be detected by any of the
SUPRARENAL FUNCTIONS. JAMA. 1927;88(20):1568–1569. doi:10.1001/jama.1927.02680460038012
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