The widespread acceptance of sulfanilamide and other sulfanilyl compounds as effective agents in the treatment of gonococcic infections has modified the value of all preexisting types of therapy. The rapidity with which many cases yield to intelligent and controlled administration of these drugs has obviated the necessity for the use of accessory therapeutic agents in such cases. The brilliance of such results has been dimmed somewhat by the development of several circumstances which will prevent the ultimate eradication of the disease: the asymptomatic carrier,1 the development of chemotherapy-fast strains of the gonococcus2 and the occurrence of relapse after apparent cure.3 Even in instances in which the patient has received what was thought to be adequate treatment, sulfanilamide may fail completely to eradicate the infection. Indeed, in a survey by Dees and Young4 of 2,727 well analyzed cases collected from the literature only 1,848 (68 per cent)
KENDELL HW, ROSE DL, SIMPSON WM. COMBINED ARTIFICIAL FEVER-CHEMOTHERAPY: IN GONOCOCCIC INFECTIONS RESISTANT TO CHEMOTHERAPY. JAMA. 1941;116(5):357–363. doi:10.1001/jama.1941.02820050001001
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