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December 30, 1933


Author Affiliations

Atlanta, Ga.
Pathologist, Grady Hospital

JAMA. 1933;101(27):2137. doi:10.1001/jama.1933.02740520047026

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To the Editor:  —Recently we have had a patient at Grady Hospital suffering from thrombocytopenic purpura haemorrhagica, probably resulting from intravenous arsenic. He was bleeding continuously from the mucous membranes. There were many large purpuric spots over the body surfaces. The blood examination revealed 2,000,000 red blood cells, 5,000 white blood cells, 65,000 platelets, and clot retraction sixty minutes plus.Repeated transfusions gave temporary support, yet it seemed that he would bleed to death in spite of all medication.Finally we administered to him ergot in 1 drachm doses every four hours, and solution of pituitary, 0.5 cc., hypodermically. Following the first two doses of ergot and one hypodermic of pituitary the bleeding diminished. After twenty-four hours slight bleeding again occurred. The medication was repeated, another transfusion was given, and after this his recovery was rapid and progressive. He is now well.The ergot and solution of pituitary were suggested

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