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Article
December 30, 1933

HISTORICAL ASPECTS OF ENZYME INVESTIGATIONS

JAMA. 1933;101(27):2137-2138. doi:10.1001/jama.1933.02740520047027

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Abstract

To the Editor:  The Journal has presented an editorial discussion of the historical aspects of enzyme investigations (The Centenary of the Discovery of Diastase, November 11, p. 1564), which I have read with great interest. Certainly all workers in this field are pleased to see the emphasis placed on the application of this study to the basic medical sciences.Priority as regards the first scientific description of enzyme activity is apparently not a matter of general agreement and I should like to call attention to some early observations that are quite commonly overlooked. Practically all books on the subject, for instance, place the priority with Dubrunfaut and with Payen and Persoz in 1830 and 1833, respectively, and this has naturally been accepted in the editorial mentioned. The first description of a practical preparation of an active "diastase" product was, no doubt, that by Payen and Persoz. However, in referring

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