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Comment & Response
November 17, 2015

Dietary Cholesterol and Blood Cholesterol Concentrations

Author Affiliations
  • 1Physicians Committee for Responsible Medicine, Washington, DC
  • 2George Washington University School of Medicine and Health Sciences, Washington, DC

Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2015;314(19):2083-2084. doi:10.1001/jama.2015.12595

To the Editor In their Viewpoint, Drs Mozaffarian and Ludwig1 asserted that dietary cholesterol does not raise blood cholesterol concentrations, echoing a similar conclusion by the Dietary Guidelines Advisory Committee in 2015. We believe they are mistaken.

A 2015 meta-analysis by Berger et al2 found that when study participants increased their dietary cholesterol by up to 650 mg per day, their total cholesterol increased an average of 12.1 mg/dL and low-density lipoprotein (LDL) cholesterol increased an average of 16.7 mg/dL compared with those who consumed less (to convert total and LDL cholesterol from mg/dL to mmol/L, multiply by 0.0529).

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