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Global Health
November 17, 2015

Novel Genetic Variant Confers Protection Against Malaria

JAMA. 2015;314(19):2014. doi:10.1001/jama.2015.15324

An international group of investigators called MalariaGEN have identified a new genetic locus in African children associated with resistance to severe malaria (Malaria Genomic Epidemiology Network. Nature. doi:10.1038/nature15390 [published online September 30, 2015]). The study reports that the locus lies near a cluster of genes that code for receptors called glycophorins, which are involved in the malaria parasite’s invasion of red blood cells.