During the past generation most of the diseases due to a deficiency of accessory food factors have been brought under control, and within the last decade many of the active principles concerned have yielded the secrets of their chemical structure. Not the least of these is the antiscorbutic substance, or "water soluble" vitamin C, a principle known to exist in limes and lemons for over a hundred years and recently found in abundance also in a large number of fruits and vegetables and in animal tissues.
As healing in tuberculosis is characterized largely by the formation of connective tissue, and the latter, according to Wolbach and his associates,1 is formed by the action of vitamin C on fibroblasts, it does not seem unreasonable to suspect that a vitamin C deficiency may be one of the causes of unfavorable trends in tuberculosis, if it does not actually contribute to exacerbations
SWEANY HC, CLANCY CL, RADFORD MH, HUNTER V. THE BODY ECONOMY OF VITAMIN C IN HEALTH AND DISEASE: WITH SPECIAL STUDIES IN TUBERCULOSIS. JAMA. 1941;116(6):469–474. doi:10.1001/jama.1941.02820060017004
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: