It has seemed to me that the average clinician spends little time in considering what physiologic mechanism may be at fault in patients who have leukopenia. One is prone to explain the condition on the basis of some abnormality in production of white blood cells by the hemopoietic tissue. While it is true that leukopenia is due in many instances to the failure of the blood-forming tissues to manufacture normal numbers of white blood cells, yet there are at least four other major mechanisms which may result in this condition. My purpose in making this presentation is to call attention to these additional conditions in the hope that all physicians may put more thought on leukopenia. With this in mind I present the following possibilities which I feel may take part in the development of leukopenia:
Diminished manufacture of white blood cells. This may be the result of (1)
LAWRENCE JS. LEUKOPENIA: A DISCUSSION OF ITS VARIOUS MODES OF PRODUCTION. JAMA. 1941;116(6):478–484. doi:10.1001/jama.1941.02820060026006
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