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Comment & Response
November 24, 2015

Cost-effectiveness of Statin Therapy for ASCVD—Reply

Author Affiliations
  • 1Department of Health Policy and Management, Harvard T. H. Chan School of Public Health, Boston, Massachusetts
  • 2Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, Massachusetts

Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2015;314(20):2191-2192. doi:10.1001/jama.2015.12928

In Reply We agree with the points Drs Luo and Kesselheim raised and have the following points to add regarding our cost-effectiveness analysis in light of these issues.

As Luo and Kesselheim noted, we used the weighted average of the lowest Red Book wholesale acquisition costs in our base-case analysis, but also paid particular attention to the price of statins when presenting our results. Specifically, we presented (1) separate cost-effectiveness analysis tables for blended generic/branded and generic-only drug prices and (2) a 1-way sensitivity analysis figure showing the optimal ASCVD treatment threshold as a function of drug cost for 3 separate cost-effectiveness thresholds ($50 000/QALY, $100 000/QALY, and $150 000/QALY).

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