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Clinical Trials Update
November 24, 2015

Mediterranean Diet With Olive Oil May Reduce Breast Cancer Risk

JAMA. 2015;314(20):2122. doi:10.1001/jama.2015.15119

Eating a Mediterranean diet supplemented with extra virgin olive oil (EVOO) was associated with a lower risk of breast cancer in a trial involving women in Spain. It’s the first randomized trial of a long-term dietary intervention to prevent breast cancer, although the study couldn’t determine whether the beneficial effect was due to the olive oil or to the Mediterranean diet (Toledo E et al. JAMA Intern Med. doi:10.1001/jamainternmed.2015.4838 [published online September 14, 2015]). The study analyzed the effects of 2 interventions: a Mediterranean diet supplemented with 1 L per week of EVOO (1476 women) or a Mediterranean diet supplemented with 30 g of mixed nuts daily (1285 women). The control group (1391 women) received advice to reduce their dietary intake of fat. This study is a secondary analysis of the large PREDIMED (Prevención con Dieta Mediterránea) trial, which was designed to test the effects of the Mediterranean diet on the primary prevention of cardiovascular disease.