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February 22, 1941

Current Comment

JAMA. 1941;116(8):708. doi:10.1001/jama.1941.02820080048014

HISTOPLASMOSIS  At relatively infrequent intervals since 1905, cases of histoplasmosis have been reported in the American literature. In that year Samuel Taylor Darling described three cases with a clinical picture somewhat similar to kala-azar but with tissues containing the organism which he named Histoplasma capsulatum. In a recent review of the subject Meleney1 discusses thirty-two cases of the disease, thirteen of which have not yet been reported in the literature and twenty-two of which were recorded in the continental United States. The disease should be suspected, Meleney points out, in patients presenting a wide variety of clinical symptoms and signs. Any condition characterized by enlargement of the liver and spleen, by generalized or regional enlargement of the lymph nodes, by an aplastic or undiagnosed secondary type of anemia or leukopenia, by generalized or localized abscesses or ulcers of the skin or by chronic pulmonary infections should lead one to