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The present bulletin records in detail the observation of Turner and his associates on mammogen, the duct growth factor of the pituitary gland. Data were secured on 545 individual cattle pituitaries, and differences in weight were found to be related to castration, sex, pregnancy and lactation. Weights of the pituitary gland, thyroid and adrenals of New Zealand rabbits also are recorded. The duct growth factor has been assayed by its ability to stimulate the normally rudimentary ducts in the breasts of the male mouse, and a unit has been defined. The chemical properties of this pituitary factor suggested that it was separate from other principles. It was distinguished from the pituitary hormones by its solubility in lipid solvents and from estrone by its heat lability. The assay of the pituitary glands from cattle indicated that the duct growth factor was low in early and late pregnancy, rising to a maximum
The Mammogenic Hormones of the Anterior Pituitary. I: The Duct Growth Factor. JAMA. 1941;116(8):797. doi:10.1001/jama.1941.02820080137033
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