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Article
February 22, 1941

The Malarial Therapy of General Paralysis and Other Conditions

JAMA. 1941;116(8):798. doi:10.1001/jama.1941.02820080138041

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Abstract

This monograph is an excellent reference manual for any physician treating neurosyphilis, especially dementia paralytica. It is essentially a review of the literature. It contains many important and practical points regarding the life cycles of the tertian, quartan and estivo-autumnal parasites. There is considerable pertinent discussion regarding the anopheline mosquito. The history of malarial therapy for dementia paralytica is also given. The author reviews the various causes of cure in the malarial therapy of dementia paralytica. The latter is compared with other treatments such as relapsing fever, sodoku, typhoid vaccine, saprovitan, sulfur, artificial hyperpyrexia, tryparsamide and artificial fever plus tryparsamide. The author's attempt to enhance the value of malarial therapy by citing instances of treatment for nonsyphilitic diseases with malaria is not necessary. There is a detailed bibliography.

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