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March 1, 1941


JAMA. 1941;116(9):838-839. doi:10.1001/jama.1941.02820090038011

Although the intravenous administration of nutrient dextrose is a method regularly employed in the clinic, this procedure furnishes no other nutritional elements except water. The requirement for electrolyte may be also readily fulfilled by the use of saline solution, and some efforts have been made to meet the nutritional and metabolic needs for fat by the intravenous administration of fine emulsions of fat.1 The problem of protein requirement is more difficult; moreover, the importance of protein in the diet frequently becomes accentuated in instances in which oral intake of this foodstuff becomes difficult or impossible. Several approaches are available for parenteral administration of protein and some of these have yielded encouraging results. It has been possible2 to maintain nitrogen equilibrium by the intravenous administration of plasma. However, the quantity of plasma required daily in order to meet the minimum protein requirements is relatively large. Furthermore, unhydrolyzed proteins, in