The introduction of a new drug or reemphasis of an old one in the therapy of asthma or other allergic conditions carries with it a grave responsibility. It is unfortunate, and often costly to the patient, to create false hopes regarding a remedy which has only a limited application or which may be actually dangerous to some of these sufferers. A large number of our patients have commented as follows: "I have tried everything that has been recommended to me, and I have spent hundreds of dollars but obtained little or no relief." Another trend of their comments is to the effect that the first two or three doses of many preparations afford magical relief, after which the beneficial response gradually or precipitously disappears. They designate this as "wearing out" the medicine, a condition probably differing somewhat from the typical development of tolerance that occurs only after long use of
LAMSON RW, BACON LC. THEOPHYLLINE MONO-ETHANOLAMINE: A CRITICAL STUDY OF ITS USE IN THE TREATMENT OF ASTHMA AND OTHER ALLERGIES. JAMA. 1941;116(10):915–921. doi:10.1001/jama.1941.02820100009003
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