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Article
June 11, 1927

THE SYNTHESIS OF THYROXIN

JAMA. 1927;88(24):1892-1893. doi:10.1001/jama.1927.02680500034015
Abstract

Modern knowledge of the function of the thyroid may be said to date from the observations of Gull in 1873 and of Ord in 1878 on the disease now known as myxedema, and the observations of Kocher and Reverdin in 1882 on what is sometimes designated as cachexia thyreopriva. In 1891 Murray showed the marked curative effect of so-called thyroid extracts in myxedema, and this fact was independently confirmed by Mackenzie in 1892 and by Fox in the same year. A few years later Magnus-Levy showed that there is a reduced heat production in myxedema, and that thyroid therapy gradually raises the oxidative processes to the normal or above it.1 An event in the study of the thyroid was the discovery of iodine as a constituent of the gland by Baumann in 1895. This was soon followed by the demonstration that certain chemical "fragments" of the tissue retained the

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