The study of the function of muscle has experienced many vicissitudes during the past century. This is due in part to the inevitable circumstance that our knowledge of certain fundamental processes associated with the phenomena of contraction has been of slow development. Thus, without a better understanding of the underlying principles of energy transformation, the dynamics of muscular performance could not be adequately interpreted. In part, progress has been delayed by the changing interests that diverted the minds of investigators from one aspect to another. At one time metabolism and the related phenomena have been regarded primarily from the energetic standpoint; at another, more purely chemical considerations have held sway. A recent writer has remarked that of late years the latter have come more to the front as a reaction against the partiality of which the defenders of the purely energetic or caloric theory of metabolism had been guilty. In
THE "PHOSPHOCREATINE" OF MUSCLE. JAMA. 1927;88(24):1894. doi:10.1001/jama.1927.02680500036017
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