For some time, we have felt that the current interest in the subject of reinfection in syphilis, particularly as an evidence of cure, has entirely overshadowed a topic of at least equal interest from the immunologic, the clinical and the public health standpoints—the incidence, diagnosis and control of infectious recurrence in early syphilis. A survey of the literature discloses approximately ten titles on the subject of reinfection to one on the subject of recurrence and mucosal or cutaneous relapse, though relapse of this type, in our experience, is fourteen times as common as reinfection in clinical practice. The relations of the two subjects are intimate, the differential considerations involved are frequently crucial, and the clinical material on reinfection is tinctured throughout with errors that arise from an imperfect comprehension of the morphology and the conditions that surround relapse. The subject of early infectious relapse is moreover one of great practical
STOKES JH, BESANCON JH, SCHOCH AG. INFECTIOUS RECURRENCE AND MUCOCUTANEOUS RELAPSE IN SYPHILISDIAGNOSIS, PUBLIC HEALTH SIGNIFICANCE AND RELATION TO TREATMENT. JAMA. 1931;96(5):344–351. doi:10.1001/jama.1931.02720310034007
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