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January 31, 1931


JAMA. 1931;96(5):360-361. doi:10.1001/jama.1931.02720310050014

Methods of scientific precision, which are applied with some success in the diagnosis, prognosis and treatment of many conditions, seem to be almost wholly lacking in the joint diseases. Any data, therefore, that offer possibilities of increased accuracy in any particular should be viewed with critical favor. The synovial fluid appears the most promising available tissue for physical, chemical or biologic study. Forkner1 has recently examined the literature on this subject and classified the data that have been obtained. It is noteworthy that there is only one reference to observations on the physical and chemical properties of normal synovial fluid. In this the pH is recorded as from 8.2 to 8.4, but Forkner remarks that the extensive work on the pH of pathologic fluids indicates that this result is too high. The report of Seeliger2 gives the specific gravity as 1.040, total solids as 4.41 per