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March 15, 1941

Absorption, Metabolism and Storage of Vitamin A and Carotene, With Some Remarks on the Vitamin A Requirement

JAMA. 1941;116(11):1184. doi:10.1001/jama.1941.02820110148029

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Approximately half the monograph is used for describing and discussing the author's own researches. The remainder is used for orientation in the chemistry of vitamin A and the carotenoids and for review and discussion of the literature. The monograph is of value not only because it gives much useful information with a direct application but also because all experiments and analytic procedures and methods are described in meticulous detail. The author is commendably critical in his interpretations and judgments. Some of the interesting conclusions reached are as follows: Serum vitamin A concentration does not represent accurately the content of the depots. No connection exists between the carotenoid concentration in serum and its vitamin A content. "Tolerance tests" give no information about the carotenoid or vitamin A contents of the organism. Even with the ingestion of large amounts, little or no vitamin A is excreted in the feces, whereas from 20

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