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June 25, 1927


JAMA. 1927;88(26):2047. doi:10.1001/jama.1927.02680520037026

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To the Editor:  —The article in The Journal (May 21, p. 1626) on the concomitance of diabetes mellitus and myelogenous leukemia is highly interesting, because of the probability of there being more than a concomitance between the two conditions. We know that polymorphonuclear leukocytes contain an enzyme similar in its action to trypsin. The inhibitory effect of trypsin on insulin in human plasma is likewise a familiar phenomenon. The fact that in some of the cases diabetes was found to have existed a variable time prior to the apparent onset of leukemia does not rule out a causal relationship between the two. Although a preleukemic or an occult leukemic period must and, in all probability, does exist, we know nothing about its duration or its manifestations. Further work on this subject might prove more than interesting.

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