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Complement Fixation in Leprosy
Dr. J. M. Gomes of São Paulo has recently studied the value of several complement fixation tests in leprosy. The Wassermann test is practically useless for diagnostic purposes since leprous serums deviate the complement with a syphilitic antigen almost as well as. syphilitic serums. The Kolmer modification and Kahn's precipitation test seem more advantageous as, according to some workers, they are absolutely negative in leprosy. The ideal reaction should be, however, positive for leprosy and negative for syphilis. Dr. Gomes aimed at three objectives: to secure one more agent for early diagnosis; a better differentiation between the two diseases, and a means of showing the coexistence of both leprosy and syphilis. Gomes described a number of his cases to show the advantage gained by treating in such coexistent infections the syphilitic process before instituting treatment for leprosy. His work followed the lines of Dreyer's and Taylor-Malone's
RIO DE JANEIRO. JAMA. 1927;89(1):45–46. doi:10.1001/jama.1927.02690010045023
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