In 1914, Inada and Ido1 demonstrated that a spirochete is the causative agent of the form of infectious jaundice characterized by sudden onset, high fever, muscle pains, renal injury and a tendency to hemorrhage. The condition is frequently referred to as Weil's disease. In Germany, Huebener and Reiter,2 and Uhlenhuth and Fromme3 reached the same conclusion, independent of the work of the Japanese investigators. Because of its special morphologic features, a new genus was formed for the organism by Noguchi,4 and it is now generally known in this country and in England as Leptospira icterohaemorrhagiae.
The relation of infectious jaundice, as seen in this country, to spirochetal jaundice, has given rise to considerable discussion. In 1923, Blumer5 was able to state that spirochetes had not been demonstrated in a single case of jaundice in the United States, and he rightly considered as entirely gratuitous the
TOWLER HH, WALKER JE. SPIROCHETAL JAUNDICE: REPORT OF A CASE. JAMA. 1927;89(2):86–89. doi:10.1001/jama.1927.02690020010004
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