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April 12, 1941

CLINICAL TETANUSTREATMENT IN 100 CONSECUTIVE CASES WITH A NET MORTALITY RATE OF 19 PER CENT

JAMA. 1941;116(15):1627-1631. doi:10.1001/jama.1941.02820150017005
Abstract

The death rate cited by various authors in cases of tetanus has usually varied from 50 to 70 per cent, or occasionally even higher. In a previous report1 our experience indicated that regardless of age, sex, incubation period, site or type of injury and provided that each patient received an initial therapeutic dose of 100,000 units of antitoxin and a total dose under 200,000 units the death rate remained approximately 50 per cent. Paterson2 reported a death rate of 27 per cent among 26 patients, all children, and the net mortality rate reported by Yodh,3 whose method of therapy is similar to ours, was 29.4 per cent in a series of 438 patients. Net rates are those which are determined from the group of patients who survive for a period longer than twenty-four hours after first being seen by the therapist.

Therefore, any method of management which

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