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Numerous references to laboratory infections with plague, typhoid, tularemia and other diseases may be found in past and current literature. Similar references to diphtheria, however, seem to be quite uncommon. The instance presented here of a clear-cut laboratory infection, establishing a definite incubation period, peculiarly supported by a control, would appear to warrant a brief report.
In a class in medical bacteriology a strain of the diphtheria bacillus was given out for cultivation, Tuesday, April 19, 1927. This strain was isolated three years ago during a local epidemic from one of a family in which four severe cases developed. Its toxicity has been repeatedly demonstrated by death of inoculated guinea-pigs within three days.
Cultures were given out on Loeffler's serum with considerable condensation water on the slants. During the course of the hour one student reported that the tube from which he inoculated had been tilted and the cotton plug
Spray RS. DIPHTHERIA: A CASE OF LABORATORY INFECTION. JAMA. 1927;89(2):112. doi:10.1001/jama.1927.92690020002011a
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