What immunotherapies for multiple sclerosis are associated with the greatest benefit and highest risk of discontinuation due to adverse events in patients with relapsing-remitting multiple sclerosis?
Alemtuzumab, natalizumab, and fingolimod were associated with the greatest benefit with regard to relapse prevention. Their association with prevention of disability worsening was unclear. Fingolimod was associated with a high risk of treatment discontinuation due to adverse events.
Irene Tramacere, Cinzia Del Giovane, Graziella Filippini. Association of Immunotherapies With Outcomes in Relapsing-Remitting Multiple Sclerosis. JAMA. 2016;315(4):409–410. doi:10.1001/jama.2015.18984