A previous communication1 presented a statistical study of heat injuries that have occurred in the United States Navy. The clinical aspects of heat injury and the several theories of its etiology, as given by various observers from biblical times until experimental work on the problem began with Claude Bernard, were cited.
In 1858, Claude Bernard2 produced deaths in birds and mammals by raising their temperatures 4 or 5 degrees C., and showed that, at autopsy, the lesions found were similar to those noted in major heat-stroke. Bernard, in a later communication, considered the cause of death to be due to purely physical causes; i. e., elevation of the blood to such a high temperature. Following this work, in 1872, H. C. Wood3 described some experimental studies. The conclusions drawn are practically the same as those of Bernard. Wood also noted that "the more violently a muscle is
HALL WW, WAKEFIELD EG. A STUDY OF EXPERIMENTAL HEAT-STROKE. JAMA. 1927;89(3):177–182. doi:10.1001/jama.1927.02690030009005
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