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Article
July 16, 1927

PERORAL ADMINISTRATION OF COLLOIDAL CONTRAST MEDIUM IN CHOLECYSTOGRAPHY

JAMA. 1927;89(3):182-187. doi:10.1001/jama.1927.02690030014006
Abstract

The substances used at present for the purpose of cholecystography are derivatives of phenolphthalein, with which they share many of its qualities. This body, a white, insoluble powder, owes its use as an indicator of free alkali to the fact that it forms brilliant red soluble salts on the addition of alkali. That it also has purgative qualities was discovered when, almost thirty years ago, the Hungarian government decreed that wine, adulterated by certain harmless additions, be earmarked by means of phenolphthalein so as to enable the poor man to buy this "necessity of life" at a price within his means. It was soon found that people partaking freely of this wine suffered from diarrhea, which led to a hasty repeal of the law and the discovery of a new purgative. Vamossy,1 who subsequently investigated this matter, found that phenolphthalein is but little absorbed from the gastro-intestinal tract, quite

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