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Comment & Response
February 2, 2016

Accounting for Missing Data in Clinical Research—Reply

Author Affiliations
  • 1Department of Emergency Medicine, Oregon Health and Science University, Portland
  • 2Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance
JAMA. 2016;315(5):518. doi:10.1001/jama.2015.16470

In Reply Dr Stevens and colleagues highlight the KNN method and further the discussion about moving away from overly simplistic, biased methods for handling missing values. Our review of missing data methods was not exhaustive. For simplicity and clarity, we focused on methods that are more common in practice and readily available in statistical software packages. As a result, we omitted certain viable techniques for handling missing values (eg, KNN, hot-deck imputation, and maximum likelihood estimation).